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Proteintech
ROBO3 Polyclonal Antibody
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Product Details
20220-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to ROBO3.
Target Information
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: axon guidance receptor; FLJ21044; retinoblastoma inhibiting gene 1; Retinoblastoma-inhibiting gene 1 protein; Rig-1; Roundabout guidance receptor 3; Roundabout homolog 3; roundabout, axon guidance receptor, homolog 3; Roundabout-like protein 3; unnamed protein product
Gene Aliases: HGPPS; HGPPS1; HGPS; RBIG1; Rig-1; RIG1; ROBO3; Robo3a; Robo3b
UniProt ID: (Human) Q96MS0, (Mouse) Q9Z2I4
Entrez Gene ID: (Human) 64221, (Rat) 315564, (Mouse) 19649
neuron migration
axon guidance
axon midline choice point recognition
chemoattraction of axon
chemorepulsion of axon
commissural neuron axon guidance
chemotaxis
multicellular organism development
nervous system development
cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
brain development
tube development
positive regulation of axonogenesis
negative regulation of negative chemotaxis
dendrite self-avoidance
positive regulation of axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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