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SCN1A Polyclonal Antibody
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Product Details
BS-1889R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SCN1A, amino acids 1901-2009.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-Feb; Brain Type I; CIN5; GEFS+2; HBSC I; HH1; RBI; SCN5A; Sodium channel protein brain I subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type I subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type I alpha polypeptide; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; unnamed protein product; Voltage-gated sodium channel subunit alpha Nav1.1
Gene Aliases: B230332M13; DEE6; DEE6A; DEE6B; DRVT; EIEE6; FEB3; FEB3A; FHM3; GEFSP2; HBSCI; NAC1; Nav1.1; SCN1; SCN1A; SMEI
UniProt ID: (Human) P35498, (Mouse) A2APX8, (Rat) P04774
Entrez Gene ID: (Human) 6323, (Mouse) 20265, (Rat) 81574
action potential
ion transport
sodium ion transport
adult walking behavior
determination of adult lifespan
neuronal action potential propagation
neuronal action potential
nerve development
ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
neuromuscular process controlling posture
detection of mechanical stimulus involved in sensory perception of pain
establishment of localization in cell
transmembrane transport
cardiac muscle cell action potential involved in contraction
membrane depolarization during action potential
regulation of presynaptic membrane potential
positive regulation of defense response to virus by host
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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