Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
SERPING1/C1 Inactivator Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
12259-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SERPING1/C1 Inactivator Fusion Protein Ag2819 (151-500 aa encoded by BC011171)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LKLYHAFSA MKKVETNMAF SPFSIASLLT QVLLGAGENT KTNLESILSY PKDFTCVHQA LKGFTTKGVT SVSQIFHSPD LAIRDTFVNA SRTLYSSSPR VLSNNSDANL ELINTWVAKN TNNKISRLLD SLPSDTRLVL LNAIYLSAKW KTTFDPKKTR MEPFHFKNSV IKVPMMNSKK YPVAHFIDQT LKAKVGQLQL SHNLSLVILV PQNLKHRLED MEQALSPSVF KAIMEKLEMS KFQPTLLTLP RIKVTTSQDM LSIMEKLEFF DFSYDLNLCG LTEDPDLQVS AMQHQTVLEL TETGVEAAAA SAISVARTLL VFEVQQPFLF MLWDQQHKFP VFMGRVYDPR A (151-500 aa encoded by BC011171)
Target Information
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: anti-thrombin 3; antithrombin; Antithrombin-III; ATIII; C1 esterase inhibitor; C1 Inh; C1 inhibitor; C1-inhibiting factor; complement component 1 inhibitor; Plasma protease C1 inhibitor; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1; serine (or cysteine) proteinase inhibitor, clade G, member 1; serine/cysteine proteinase inhibitor clade G member 1; Serpin C1; Serpin G1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor clade G member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C, member 1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Gene Aliases: AI114908; At-3; AT3; AT3D; ATIII; C1IN; C1INH; C1NH; HAE1; HAE2; PRO0309; SERPINC1; SERPING1; THPH7
UniProt ID: (Human) P01008, (Human) P05155, (Mouse) P32261, (Mouse) P97290
Entrez Gene ID: (Human) 462, (Human) 710, (Mouse) 11905, (Mouse) 12258
response to nutrient
blood coagulation
negative regulation of endopeptidase activity
negative regulation of inflammatory response
regulation of blood coagulation, intrinsic pathway
negative regulation of complement activation, lectin pathway
platelet degranulation
complement activation, classical pathway
aging
blood coagulation, intrinsic pathway
blood circulation
fibrinolysis
innate immune response
hemostasis
negative regulation of peptidase activity
immune system process
regulation of blood coagulation
negative regulation of complement activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support