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Proteintech
SERPING1/C1 Inactivator Polyclonal Antibody
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Product Details
12259-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SERPING1/C1 Inactivator Fusion Protein Ag2819 (151-500 aa encoded by BC011171)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LKLYHAFSA MKKVETNMAF SPFSIASLLT QVLLGAGENT KTNLESILSY PKDFTCVHQA LKGFTTKGVT SVSQIFHSPD LAIRDTFVNA SRTLYSSSPR VLSNNSDANL ELINTWVAKN TNNKISRLLD SLPSDTRLVL LNAIYLSAKW KTTFDPKKTR MEPFHFKNSV IKVPMMNSKK YPVAHFIDQT LKAKVGQLQL SHNLSLVILV PQNLKHRLED MEQALSPSVF KAIMEKLEMS KFQPTLLTLP RIKVTTSQDM LSIMEKLEFF DFSYDLNLCG LTEDPDLQVS AMQHQTVLEL TETGVEAAAA SAISVARTLL VFEVQQPFLF MLWDQQHKFP VFMGRVYDPR A (151-500 aa encoded by BC011171)
Target Information
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: anti-thrombin 3; antithrombin; Antithrombin-III; antithrombin-III precursor; ATIII; C1 esterase inhibitor; C1 Inh; C1 inhibitor; C1-inhibiting factor; C1-inhibitor; complement component 1 inhibitor; epididymis secretory sperm binding protein; plasma protease (C1) inhibitor precursor; Plasma protease C1 inhibitor; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1; serine (or cysteine) proteinase inhibitor, clade G, member 1; serine/cysteine proteinase inhibitor clade G member 1; Serpin C1; Serpin G1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor clade G (C1 inhibitor) member 1 isoform SERPING1_1; serpin peptidase inhibitor clade G (C1 inhibitor) member 1 isoform SERPING1_2; serpin peptidase inhibitor clade G (C1 inhibitor) member 1 isoform SERPING1_3; serpin peptidase inhibitor clade G (C1 inhibitor) member 1 isoform SERPING1_4; serpin peptidase inhibitor clade G member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C, member 1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; SERPING1; unnamed protein product
Gene Aliases: AI114908; At-3; AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; C1IN; C1INH; C1NH; HAE1; HAE2; PRO0309; SERPINC1; SERPING1; THPH7
UniProt ID: (Human) P01008, (Human) P05155, (Mouse) P32261, (Mouse) P97290
Entrez Gene ID: (Human) 462, (Human) 710, (Mouse) 11905, (Mouse) 12258
blood coagulation
hemostasis
regulation of blood coagulation
negative regulation of complement activation, lectin pathway
blood circulation
fibrinolysis
response to nutrient
negative regulation of peptidase activity
negative regulation of endopeptidase activity
negative regulation of inflammatory response
regulation of blood coagulation, intrinsic pathway
immune system process
complement activation, classical pathway
innate immune response
negative regulation of complement activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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