Proteintech

SH2D3C Polyclonal Antibody

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SH2D3C Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 12882-1-AP (SH2D3C antibody) at dilution of 1:100 (under 10x lens).

SH2D3C Antibody in Western Blot (WB) — Human placenta tissue were subjected to SDS PAGE followed by western blot with 12882-1-AP (SH2D3C antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours.

SH2D3C Antibody in Immunoprecipitation (IP) — IP result of anti-SH2D3C (IP:12882-1-AP, 3ug; Detection:12882-1-AP 1:500) with mouse brain tissue lysate 6000ug.

Product Details

12882-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2400	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunoprecipitation (IP)	0.5-4.0 µg	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	SH2D3C Fusion Protein Ag3887 (354-703 aa encoded by BC027962) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.23 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: TETSSQQAR SYGERLKELS ENGAPEGDWG KTFTVPIVEV TSSFNPATFQ SLLIPRDNRP LEVGLLRKVK ELLAEVDART LARHVTKVDC LVARILGVTK EMQTLMGVRW GMELLTLPHG RQLRLDLLER FHTMSIMLAV DILGCTGSAE ERAALLHKTI QLAAELRGTM GNMFSFAAVM GALDMAQISR LEQTWVTLRQ RHTEGAILYE KKLKPFLKSL NEGKEGPPLS NTTFPHVLPL ITLLECDSAP PEGPEPWGST EHGVEVVLAH LEAARTVAHH GGLYHTNAEV KLQGFQARPE LLEVFSTEFQ MRLLWGSQGA SSSQARRYEK FDKVLTALSH KLEPAVRSSE L (354-703 aa encoded by BC027962)

Target Information

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation.

Neuroscience

Gomi F,Uchida Y,Endo S

Tue Aug 21 00:00:00 EDT 2018

Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation.

Neuroscience

Gomi F,Uchida Y,Endo S

Tue Aug 21 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: Cas/HEF1-associated signal transducer; Chat-H; Novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1; SH2 domain-containing protein 3C; SHEP1

Gene Aliases: CHAT; NSP3; PRO34088; SH2D3C; SHEP1; UNQ272/PRO309/PRO34088

UniProt ID: (Human) Q8N5H7, (Mouse) Q9QZS8

Entrez Gene ID: (Human) 10044, (Mouse) 27387, (Rat) 362111

Function(s)

signal transduction transmembrane receptor protein tyrosine kinase signaling pathway small GTPase mediated signal transduction positive regulation of signal transduction positive regulation of GTPase activity JNK cascade

Process(es)

SH3/SH2 adaptor activity guanyl-nucleotide exchange factor activity protein binding transmembrane receptor protein tyrosine kinase adaptor activity

SH2D3C Polyclonal Antibody

Product Details

12882-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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