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SIRT4 Polyclonal Antibody

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SIRT4 Polyclonal Antibody

Product Details

BS-7537R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4, amino acids 51-150.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; sirtuin type 4; yeast silent information regulator 2 (Sir2p) homolog; similar to prokaryotic sirtuins

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Gene Aliases: 4930596O17Rik; SIR2L4; SIRT4

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UniProt ID: (Human) Q9Y6E7, (Mouse) Q8R216

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Entrez Gene ID: (Human) 23409, (Mouse) 75387, (Rat) 304539

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Function(s)
NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding zinc ion binding transferase activity transferase activity, transferring acyl groups other than amino-acyl groups transferase activity, transferring glycosyl groups nucleotidyltransferase activity NAD-dependent protein deacetylase activity metal ion binding NAD binding lipoamidase activity NAD+ binding NAD-dependent protein lipoamidase activity NAD-dependent protein biotinidase activity NAD+-protein-cysteine ADP-ribosyltransferase activity protein ADP-ribosylase activity imidazoleglycerol-phosphate synthase activity protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity hydrolase activity NAD(P)-cysteine ADP-ribosyltransferase activity NAD(P)-asparagine ADP-ribosyltransferase activity NAD(P)-serine ADP-ribosyltransferase activity iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity N-acetylcitrulline deacetylase activity purine deoxyribosyltransferase activity N-acetylgalactosamine-6-phosphate deacetylase activity diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity molecular_function
Process(es)
protein ADP-ribosylation glutamine metabolic process cellular response to DNA damage stimulus negative regulation of cardiac muscle cell apoptotic process peptidyl-lysine deacetylation negative regulation of fatty acid oxidation negative regulation of insulin secretion positive regulation of lipid biosynthetic process tricarboxylic acid metabolic process negative regulation of protein processing involved in protein targeting to mitochondrion cellular response to hypoxia regulation of glutamine family amino acid metabolic process mitochondrion organization negative regulation of pyruvate decarboxylation to acetyl-CoA
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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