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Invitrogen
SLIT3 Polyclonal Antibody
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Product Details
PA5-62445
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLIT3
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Immunogen sequence: CDNKNDSANA CSAFKCHHGQ CHISDQGEPY CLCQPGFSGE HCQQENPCLG QVVREVIRRQ KGYASCATAS KVPIMECRG
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 89%.
Target Information
Slit guidance ligand 3 (SLIT3) is a gene located on chromosome 5q35.1, encoding a member of the SLIT family of proteins that play key roles in axon guidance and neuronal migration during development. SLIT3 functions as a secreted protein, influencing the directional growth and pathfinding of axons by interacting with its receptor, Robo, on the surface of neurons. This interaction is critical for establishing neural network architecture and maintaining proper neural connectivity. Beyond its role in the nervous system, SLIT3 is involved in processes such as angiogenesis and cell migration, impacting tissue development and repair. Dysregulation of SLIT3 expression or function has been associated with developmental abnormalities and various diseases, including cancer, where it may influence tumor cell invasion and metastasis. Research into SLIT3 continues to explore its therapeutic potential in modulating axon guidance and its implications in pathological conditions affecting both the nervous and vascular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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