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Invitrogen
SP3 Polyclonal Antibody
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Product Details
PA5-80057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SP3 (569-599aa NTNDLTHLRVQVVDEEGDQQHQEGKRLRRVA).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: PC-12 whole cell, HEPA whole cell, HELA whole cell. IHC: mouse lung tissue, rat lung tissue, human intestinal cancer tissue.
Target Information
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686O1631; GC-binding transcription factor Sp3; specificity protein 3; SPR-1; SPR-2; SPR1; trans-acting transcription factor 3; Transcription factor Sp3
Gene Aliases: D130027J01Rik; SP3; SPR2
UniProt ID: (Human) Q02447, (Mouse) O70494
Entrez Gene ID: (Human) 6670, (Mouse) 20687, (Rat) 367846
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
metal ion binding
nucleic acid binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
ossification
natural killer cell differentiation
trophectodermal cell differentiation
liver development
embryonic placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
protein sumoylation
B cell differentiation
T cell differentiation
megakaryocyte differentiation
monocyte differentiation
lung development
granulocyte differentiation
enucleate erythrocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
embryonic skeletal system development
embryonic process involved in female pregnancy
definitive hemopoiesis
in utero embryonic development
transcription from RNA polymerase II promoter
erythrocyte differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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