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SPHK1 Polyclonal Antibody

View all (29) SPHK1 antibodies

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SPHK1 Polyclonal Antibody

Product Details

SPHK1-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 50-100 on human SPHK1 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acetyltransferase SPHK1; RP23-193A16.4; SK 1; SKase; Sphingosine kinase 1; SPK 1; unnamed protein product

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Gene Aliases: 1110006G24Rik; SK1; SPHK; SPHK1; SPK; Spk1

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UniProt ID: (Human) Q9NYA1, (Rat) Q91V26, (Mouse) Q8CI15

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Entrez Gene ID: (Human) 8877, (Rat) 170897, (Mouse) 20698

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Function(s)
nucleotide binding magnesium ion binding lipid kinase activity DNA binding protein binding calmodulin binding ATP binding lipid binding sphinganine kinase activity kinase activity acetyltransferase activity transferase activity sphingosine-1-phosphate receptor activity protein phosphatase 2A binding NAD+ kinase activity diacylglycerol kinase activity D-erythro-sphingosine kinase activity kinase
Process(es)
blood vessel development sphingosine-1-phosphate signaling pathway protein acetylation lipid metabolic process sphingosine metabolic process inflammatory response brain development cell proliferation positive regulation of cell proliferation regulation of gene expression positive regulation of peptidyl-threonine phosphorylation regulation of tumor necrosis factor-mediated signaling pathway calcium-mediated signaling regulation of endocytosis sphingolipid biosynthetic process positive regulation of cell growth positive regulation of cell migration positive regulation of protein ubiquitination regulation of interleukin-1 beta production positive regulation of interleukin-17 production regulation of cellular amide metabolic process response to tumor necrosis factor intracellular signal transduction cellular response to vascular endothelial growth factor stimulus negative regulation of apoptotic process positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of mitotic cell cycle positive regulation of smooth muscle contraction sphingosine biosynthetic process sphingoid catabolic process regulation of lipid biosynthetic process positive regulation of fibroblast proliferation regulation of phagocytosis regulation of transport positive regulation of NF-kappaB transcription factor activity regulation of multicellular organismal process cellular response to hydrogen peroxide cellular response to growth factor stimulus DNA biosynthetic process sphingolipid mediated signaling pathway regulation of neuroinflammatory response negative regulation of ceramide biosynthetic process positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling regulation of microglial cell activation regulation of endosomal vesicle fusion positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion protein kinase C-activating G-protein coupled receptor signaling pathway female pregnancy cellular response to starvation positive regulation of neuron projection development response to organic cyclic compound response to amine cyclooxygenase pathway response to magnesium ion response to progesterone response to ATP positive regulation of NF-kappaB import into nucleus lipid phosphorylation response to interleukin-1 phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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