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A suggested positive control is mouse heart tissue lysate.
PA5-21170 can be used with blocking peptide PEP-1284.
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
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Protein Aliases: 2310076E16Rik; cardiomyopathy associated 5; Cardiomyopathy-associated protein 5; Dystrobrevin-binding protein 2; Genethonin-3; heart and skeletal muscle-specific and sprouty domain-containing; Myospryn; SPRY domain-containing protein 2; stretch response protein 553; stretch-response protein 553; stretch-responsive fibronectin protein type 3; TRIM-like protein; tripartite motif-containing 76; Tripartite motif-containing protein 76
Gene Aliases: 2310076E16Rik; 2310076E21Rik; AA420382; AI504003; C5orf10; CMYA5; DTNBP2; SPRYD2; sr553; Srfsd; Tims; TRIM76
UniProt ID: (Human) Q8N3K9
Molecular Function: ubiquitin-protein ligase