|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 260-305 of human SRSF11|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 54 kDa.
Purity is >95% by SDS-PAGE.
Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns that are required for accurate splice site recognition and the control of alternative splicing. Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20 and SF2/ASF. The family of SR factors all contain one or more RNA recognition motifs (RRM) and a SR-rich domain. The SR factor family is not only essential for constitutive splicing, but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. SFRS11 (splicing factor, arginine/serine-rich 11), also known as arginine-rich 54 kDa nuclear protein (p54) or NET2, is a 484 amino acid nuclear protein that colocalizes with spliceosome components and belongs to the splicing factor SR family. SFRS11 may function in pre-mRNA splicing and contains one RRM (RNA recognition motif) domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Arginine-rich 54 kDa nuclear protein; arginine/serine-rich 11; p54; Serine/arginine-rich splicing factor 11; SFRS11; Splicing factor; splicing factor p54; Splicing factor, arginine/serine-rich 11; SR splicing factor 11
Gene Aliases: 0610009J05Rik; 2610019N13Rik; BF642805; dJ677H15.2; NET2; p54; SFRS11; SRSF11
UniProt ID: (Human) Q05519
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