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Bethyl Laboratories
STAT2 Polyclonal Antibody
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FIGURE: 1 / 2
STAT2 Antibody (A303-510A) in IHC (P)
Detection of human STAT2 by immunohistochemistry. Samples: FFPE serial sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-STAT2 (Product # A303-510A) (Lot 1, left panel), (Product # A303-511A) (Lot 1, middle panel) and (Product # A303-512A) (Lot 1, right panel) used at a dilution of 1:1,000 (1 µg/mL) or 1:200 (1 µg/mL). Detection: DAB.
Product Details
A303-510A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 175 and 225 of Human Signal Transducer and Activator of Transcription 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: interferon alpha induced transcriptional activator; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT; STAT 2; STAT-2; unnamed protein product
Gene Aliases: IMD44; ISGF-3; P113; PTORCH3; STAT113; STAT2
UniProt ID: (Human) P52630
Entrez Gene ID: (Human) 6773
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
ubiquitin-like protein ligase binding
regulation of protein phosphorylation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
signal transduction
JAK-STAT cascade
regulation of cell proliferation
response to peptide hormone
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
type I interferon signaling pathway
negative regulation of type I interferon-mediated signaling pathway
regulation of mitochondrial fission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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