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Invitrogen
SUMO2/SUMO3/SUMO4 Polyclonal Antibody
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FIGURE: 1 / 3
SUMO2/SUMO3/SUMO4 Antibody (PA5-103276) in IHC (P)
Immunohistochemistry analysis of SUMO2/SUMO3/SUMO4 in human esophageal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SUMO2/SUMO3/SUMO4 polyclonal antibody (Product # PA5-103276) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103276
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SUMO2(Accession P61956), corresponding to amino acid residues M1-Q51.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Sumo2/3/4.
Target Information
SUMO proteins and ubiquitin post translationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HSMT3; insulin-dependent diabetes mellitus 5; sentrin 2; Sentrin-2; small ubiquitin-like modifier 4 protein; Small ubiquitin-like protein 4; Small ubiquitin-related modifier 2; Small ubiquitin-related modifier 3; Small ubiquitin-related modifier 4; SMT3 (supressor of mif two, 3) homolog 1; SMT3 homolog 1; SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 2-like; SMT3 suppressor of mif two 3 homolog 3; SMT3 suppressor of mif two 3 homolog 4; SMT3 supressor of mif two 3 homolog 2; Smt3A; Smt3B; SMT3H1; SUMO-2; SUMO-3; SUMO-4; SUMO4; small ubiquitin-like modifier; Ubiquitin-like protein SMT3A; Ubiquitin-like protein SMT3B; unnamed protein product
Gene Aliases: 2810014B19Rik; D10Ertd345e; dJ281H8.4; HSMT3; IDDM5; SMT3A; SMT3B; SMT3H1; SMT3H2; SMT3H4; SUMO-2; SUMO-3; SUMO-4; SUMO2; SUMO3; SUMO4
UniProt ID: (Human) P61956, (Human) P55854, (Human) Q6EEV6, (Rat) P61959, (Mouse) P61957, (Rat) Q5XIF4, (Mouse) Q9Z172
Entrez Gene ID: (Human) 6613, (Human) 6612, (Human) 387082, (Rat) 690244, (Mouse) 170930, (Rat) 682787, (Rat) 499417, (Mouse) 20610
protein sumoylation
negative regulation of DNA binding
regulation of protein localization to nucleus
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
cellular protein localization
negative regulation of transcription, DNA-templated
protein localization to nucleus
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of DNA binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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