This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: adipocyte; adiponectin; FP17469; HGNC:11433; Neuron-specific antigen HPC-1; P35A; P35B; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; syntaxin 1B1; syntaxin 1B2; Syntaxin 2; syntaxin a/b; Syntaxin-1A; Syntaxin-1B; Syntaxin-1B1; Syntaxin-1B2
Gene Aliases: GEFSP9; HPC-1; P35-1; Sap; STX1; STX1A; STX1B; STX1B1; STX1B2; Stx1bl; Stx2; SYN1A; Syn1b
Molecular Function: SNARE protein