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OriGene
MAP2K1 Monoclonal Antibody (OTI7B1), Biotin, TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
TA700334
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI7B1
Immunogen
Full length human recombinant protein of human MAP2K1 produced in HEK293T cell.
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 10mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK2; MKK (Thr292); MKK (Thr386); MKK2; MP2K1; PRKMK2; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product
Gene Aliases: CFC3; MAPKK1; MEK1; MEL; MKK1; PRKMK1
UniProt ID: (Human) Q02750
Entrez Gene ID: (Human) 5604
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
MAP-kinase scaffold activity
protein binding
ATP binding
protein kinase binding
protein kinase activator activity
small GTPase binding
mitogen-activated protein kinase kinase kinase binding
protein serine/threonine kinase activator activity
macromolecular complex binding
scaffold protein binding
protein serine kinase activity
MAPK cascade
regulation of vascular smooth muscle contraction
chemotaxis
response to oxidative stress
signal transduction
neuromuscular junction development
negative regulation of cell proliferation
positive regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
Schwann cell development
neuron differentiation
positive regulation of cell migration
melanosome transport
regulation of stress-activated MAPK cascade
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of homotypic cell-cell adhesion
ERBB signaling pathway
ERBB2-ERBB3 signaling pathway
myelination
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
positive regulation of muscle contraction
vesicle transport along microtubule
insulin-like growth factor receptor signaling pathway
Golgi inheritance
response to axon injury
neuron projection morphogenesis
response to glucocorticoid
triglyceride homeostasis
ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
cellular senescence
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
regulation of early endosome to late endosome transport
positive regulation of ATP biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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