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OriGene
MUC1 Monoclonal Antibody (OTI4A5), Biotin, TrueMAB™
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Product Details
TA700446
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4A5
Immunogen
Full length human recombinant protein of human MUC1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 10mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. MUC1 is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. MUC1 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation of the MUC1 protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of the MUC1 gene have been reported, but the full-length nature of only some has been determined. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Breast carcinoma-associated antigen DF3; CA 15-3; Cancer antigen 15-3; Carcinoma-associated mucin; CD227; cell membrane protein; DF3 antigen; EMA; Episialin; H23 antigen; H23AG; J19; KL-6; Krebs von den Lungen-6; MUC-1; MUC1; MUC1-alpha; MUC1/E1; transmembrane; devoid of tandem repeats; MUC1/E2; transmembrane; devoid of tandem repeats; longer signal peptide; MUC1/F; transmembrane; MUC1/G; transmembrane; devoid of tandem repeats; MUC1/PC1; MUC1/PC2; MUC1/S1; potential secreted protein; MUC1/S2; potential secreted protein; MUC1/S; potential secreted protein with no tandem repeats; MUC1/SV1; MUC1/SV10; MUC1/SV2; MUC1/SV3; MUC1/SV4; MUC1/SV7; MUC1/SV8; MUC1/SV9; mucin 1, transmembrane; mucin glycoprotein; mucin short variant Y; transmembrane; devoid of tandem repeats; Mucin-1; Peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; short variant; tumor associated epithelial mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin; Unknown; unnamed protein product
Gene Aliases: ADMCKD; ADMCKD1; ADTKD2; CA 15-3; Ca15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1/ZD; PEM; PEMT; PUM
UniProt ID: (Human) P15941
Entrez Gene ID: (Human) 4582
negative regulation of transcription by competitive promoter binding
DNA damage response, signal transduction by p53 class mediator
mitotic G1 DNA damage checkpoint
negative regulation of cell adhesion mediated by integrin
positive regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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