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TBL1 Polyclonal Antibody
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Product Details
BS-4219R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TBL1X.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box-like/WD repeat-containing protein TBL1X; F-box-like/WD repeat-containing protein TBL1Y; SMAP55; transducin beta like 1X-linked; transducin beta-like 1; Transducin beta-like protein 1X; Transducin beta-like protein 1Y; Transducin-beta-like protein 1, X-linked; Transducin-beta-like protein 1, Y-linked; unnamed protein product
Gene Aliases: 5330429M20; CHNG8; DFNY2; EBI; RGD1563868; SMAP55; TBL1; TBL1X; TBL1Y
UniProt ID: (Human) O60907, (Human) Q9BQ87, (Mouse) Q9QXE7
Entrez Gene ID: (Human) 6907, (Human) 90665, (Mouse) 21372, (Rat) 302711
transcription regulatory region sequence-specific DNA binding
transcription corepressor activity
protein binding
histone binding
identical protein binding
DNA binding
chromatin binding
beta-catenin binding
protein C-terminus binding
transcription factor binding
protein domain specific binding
transcription regulatory region DNA binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
proteolysis
sensory perception of sound
histone deacetylation
proteasome-mediated ubiquitin-dependent protein catabolic process
response to estrogen
fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to steroid hormone
canonical Wnt signaling pathway
biological_process
protein stabilization
positive regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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