PA1-24459 detects Hepatocyte Nuclear Factor 1-beta (TCF2) in Human samples.
PA1-24459 has been successfully used in Western Blot procedures.
PA1-24459 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human TCF2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Hepatocyte Nuclear Factor 1? (HNF-1?, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor ) is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF1 beta A; Homeoprotein LFB3; TCF-2; Transcription factor 2; transcription factor 2, hepatic; Variant hepatic nuclear factor 1; vHNF1
Gene Aliases: FJHN; HNF-1-beta; HNF-1B; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
UniProt ID: (Human) P35680
Entrez Gene ID: (Human) 6928