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Proteintech
TCOF1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
11003-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TCOF1 Fusion Protein Ag1447 (1-350 aa encoded by BC014559)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAEARKRRE LLPLIYHHLL RAGYVRAARE VKEQSGQKCF LAQPVTLLDI YTHWQQTSEL GRKRKAEEDA ALQAKKTRVS DPISTSESSE EEEEAEAETA KATPRLASTN SSVLGADLPS SMKEKAKAET EKAGKTGNSM PHPATGKTVA NLLSGKSPRK SAEPSANTTL VSETEEEGSV PAFGAAAKPG MVSAGQADSS SEDTSSSSDE TDVEGKPSVK PAQVKASSVS TKESPARKAA PAPGKVGDVT PQVKGGALPP AKRAKKPEEE SESSEEGSES EEEAPAGTRS QVKASEKILQ VRAASAPAKG TPGKGATPAP PGKAGAVASQ TKAGKPEEDS ESSSEESSDS E (1-350 aa encoded by BC014559)
Target Information
Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacle protein
Gene Aliases: AA408847; AW209012; TCOF1; treacle
UniProt ID: (Mouse) O08784
Entrez Gene ID: (Mouse) 21453
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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