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Proteintech
THAP1 Polyclonal Antibody
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Product Details
12584-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
THAP1 Fusion Protein Ag3285 (1-213 aa encoded by BC021721)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
12584-1-AP is a rabbit polyclonal antibody raised against full-length of human THAP1.
Immunogen sequence: MVQSCSAYG CKNRYDKDKP VSFHKFPLTR PSLCKEWEAA VRRKNFKPTK YSSICSEHFT PDCFKRECNN KLLKENAVPT IFLCTEPHDK KEDLLEPQEQ LPPPPLPPPV SQVDAAIGLL MPPLQTPVNL SVFCDHNYTV EDTMHQRKRI HQLEQQVEKL RKKLKTAQQR CRRQERQLEK LKEVVHFQKE KDDVSERGYV ILPNDYFEIV EVPA (1-213 aa encoded by BC021721)
Target Information
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 4833431A01Rik; nuclear proapoptotic factor; THAP domain containing, apoptosis associated protein 1; THAP domain protein 1; THAP domain-containing apoptosis-associated protein 1; THAP domain-containing protein 1; THAP1; unnamed protein product
Gene Aliases: 4833431A01Rik; AW490810; DYT6; THAP1
UniProt ID: (Human) Q9NVV9, (Mouse) Q8CHW1, (Rat) Q5U208
Entrez Gene ID: (Human) 55145, (Mouse) 73754, (Rat) 306547
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
nucleic acid binding
zinc finger transcription factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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