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Product Details
A300-955A
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
Assay-dependent | - |
Immunoprecipitation (IP) |
2-5 µg/mg lysate | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Between 375 and 425 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
tris citrate/phosphate, pH 7-8 |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse and X. laevis
Target Information
THRAP3 is a 955 amino acid novel nuclear receptor and a member of the Thyroid hormone receptor associated proteins with a LISH domain and no obvious known sequence motifs. THRAP3 is a 150 kDa subunit of the large multiprotein complex TRAP and is important in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It is also known to play an important role in transcriptional coactivation. It is known to interact with DKC1, nop5/nap65 and fibrillarin. From the Northern blot analysis of several human tissues it was found that TRAP150 is ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCLAF1 and THRAP3 family member 2; Thyroid hormone receptor-associated protein 3; Thyroid hormone receptor-associated protein complex 150 kDa component; thyroid hormone receptor-associated protein, 150 kDa subunit; Trap150
Gene Aliases: BCLAF2; THRAP3; TRAP150
UniProt ID: (Human) Q9Y2W1
Entrez Gene ID: (Human) 9967
Molecular Function:
nucleic acid metabolism protein
regulation of alternative mRNA splicing, via spliceosome
nuclear-transcribed mRNA catabolic process
transcription initiation from RNA polymerase II promoter
mRNA processing
circadian rhythm
RNA splicing
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
positive regulation of circadian rhythm
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mRNA splicing, via spliceosome
mRNA stabilization
core promoter sequence-specific DNA binding
RNA polymerase II transcription cofactor activity
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
ATP binding
ligand-dependent nuclear receptor transcription coactivator activity
vitamin D receptor binding
poly(A) RNA binding
thyroid hormone receptor binding
phosphoprotein binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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