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Invitrogen
TMC1 Polyclonal Antibody
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FIGURE: 1 / 4
TMC1 Antibody (PA5-97128) in IHC (P)
Immunohistochemistry analysis of TMC1 in paraffin-embedded human esophagus. Samples were incubated with TMC1 Polyclonal antibody (Product # PA5-97128) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-97128
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human TMC1 (NP_6196362)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
44 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: INILRLHTSM YFQCWAVMCC NVPEARVFKA SRSNNFYLGM LLLILFLSTM PVLYMIVSLP PSFDCGPFSG KNRMFEVIGE TLEHDFPSWM AKILRQLSNP G; Positive Samples: Mouse eye; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beethoven protein; Deafness protein; transmembrane channel-like 1; Transmembrane channel-like protein 1; Transmembrane cochlear-expressed protein 1; transmembrane, cochlear expressed 1; transmembrane, cochlear expressed, 1; unnamed protein product
Gene Aliases: 4933416G09Rik; Beethoven; Bth; CWEA1; DFNA36; DFNB11; DFNB7; dn; TMC1
UniProt ID: (Human) Q8TDI8, (Mouse) Q8R4P5
Entrez Gene ID: (Human) 117531, (Mouse) 13409, (Rat) 361739
transport
ion transport
sensory perception of sound
regulation of ion transmembrane transport
detection of mechanical stimulus involved in sensory perception of sound
vestibular reflex
auditory receptor cell development
calcium ion transmembrane transport
biological_process
ion transmembrane transport
regulation of calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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