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Invitrogen
TMEM52B Polyclonal Antibody
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FIGURE: 1 / 2
TMEM52B Antibody (PA5-144059) in WB
Western blot analysis of TMEM52B using TMEM52B antibody (Product # PA5-144059). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: human 293T whole cell lysates; Lane 2: monkey COS-7 whole cell lysates; Lane 3: human SiHa whole cell lysates; Lane 4: rat kidney tissue lysates; Lane 5: rat NRK whole cell lysates; Lane 6: mouse kidney tissue lysates; Lane 7: mouse HBZY-1 whole cell lysat... View More
Product Details
PA5-144059
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human TMEM52B recombinant protein (Position: T22-N183).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human 293T whole cell, monkey COS-7 whole cell, human SiHa whole cell, rat kidney tissue, rat NRK whole cell, mouse kidney tissue, mouse HBZY-1 whole cell. Flow: RT4 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The TMEM52B gene encodes a transmembrane protein that is widely expressed across various normal human tissues, suggesting its fundamental role in maintaining cellular integrity. TMEM52B is part of the transmembrane protein (TMEM) family, which contains proteins that span biological membranes, including the lipid bilayer of the plasma membrane and organelle membranes. This gene is notably involved in tumor biology, where it modulates cancer cell survival and invasion. Studies have shown that suppression of TMEM52B expression can enhance the aggressiveness of cancer cells, indicating its potential as a tumor suppressor gene. Specifically, TMEM52B isoforms such as P18 and P20 have been found to differentially influence tumor dynamics, particularly in the context of nasopharyngeal carcinoma (NPC). While its exact molecular mechanisms remain largely unknown, the regulation of TMEM52B is crucial for controlling tumor growth and metastasis. Therefore, understanding its role could provide insights into therapeutic strategies aimed at curbing cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane protein 52B; unnamed protein product
Gene Aliases: C12orf59; D630042F21Rik; TMEM52B; UNQ5927/PRO19821
UniProt ID: (Human) Q4KMG9, (Mouse) Q0VBF2
Entrez Gene ID: (Human) 120939, (Rat) 689963, (Mouse) 330428
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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