Immunogen sequence: MLPEAGSLW LLKLLRDIQL AQFYWPILEE LNVTRPEHFD FVKPEDLDGI GMGRPAQRRL SEALKRLRSG PKSKNWVYKI LGGFAPEHKE PTLPSDSPRH LPEPEGGLKC LIPEGAVCRG ELLGSGCFGV VHRGLWTLPS GKSVPVAVKS LRVGPEGPMG TELGDFLREV SVMMNLEHPH VLRLHGLVLG QPLQMVMELA PLGSLHARLT APAPTPPLLV ALLCLFLRQL AGAMAYLGAR GLVHRDLATR NLLLASPRTI KVADFGLVRP LGGARGRYVM GGPRPIPYAW CAPESLRHGA FSSASDVWMF GVTLWEMFSG GEEPWAGVPP YLILQRLEDR ARLPRPPLCS RALYSLALRC WAPHPADRPS FSHLEGLL (1-377 aa encoded by BC035782)
TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene.
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Protein Aliases: CD38 negative kinase 1; Kinase of embryonic stem cells; MGC46193; non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor 1; tyrosine kinase, non-receptor, 1
Gene Aliases: Kos1; TNK1; Tnk1a; Tnk1b