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Proteintech
TOLLIP Polyclonal Antibody
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Product Details
11315-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TOLLIP Fusion Protein Ag1864 (1-274 aa encoded by BC012057)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATTVSTQR GPVYIGELPQ DFLRITPTQQ QRQVQLDAQA AQQLQYGGAV GTVGRLNITV VQAKLAKNYG MTRMDPYCRL RLGYAVYETP TAHNGAKNPR WNKVIHCTVP PGVDSFYLEI FDERAFSMDD RIAWTHITIP ESLRQGKVED KWYSLSGRQG DDKEGMINLV MSYALLPAAM VMPPQPVVLM PTVYQQGVGY VPITGMPAVC SPGMVPVALP PAAVNAQPRC SEEDLKAIQD MFPNMDQEVI RSVLEAQRGN KDAAINSLLQ MGEEP (1-274 aa encoded by BC012057)
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adapter protein; FLJ33531; Toll-interacting protein; tollip {ECO:0000312|EMBL:AAI33068.1}
Gene Aliases: 4930403G24Rik; 4931428G15Rik; IL-1RAcPIP; TOLLIP
UniProt ID: (Human) Q9H0E2, (Rat) A2RUW1, (Mouse) Q9QZ06
Entrez Gene ID: (Human) 54472, (Rat) 361677, (Mouse) 54473
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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