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Product Details
PA5-28273
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 172 of Human TCTP
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545749
Product Specific Information
Recommended positive controls: mouse brain.
Predicted reactivity: Mouse (95%), Rat (95%), Pig (100%), Rabbit (98%), Chicken (90%), Sheep (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%), Guinea pig (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa polypeptide; 21 kDa polypeptide under translational control; Fortilin; Histamine-releasing factor; HRF; p21; p23; TCTP; translationally regulated transcript (21 kDa); Translationally-controlled tumor protein
Gene Aliases: HRF; p02; p21; p23; TCTP; TPT1; Trt
UniProt ID: (Human) P13693, (Mouse) P63028
Entrez Gene ID: (Human) 7178, (Mouse) 22070
calcium ion transport
cellular calcium ion homeostasis
response to virus
cell differentiation
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
stem cell population maintenance
negative regulation of ectoderm development
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