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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (HGQKPGTHPPSELD) corresponding to the C-terminus amino acids of TREM2|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues.
PA5-18763 was used in western blot to report on the ability of antibodies to detect TREM2 in neuronal but not microglial tissue from Alzheimer's diseased brain
|Satoh J,Kawana N,Yamamoto Y,Ishida T,Saito Y,Arima K||Alzheimer's research & therapy (5:null)||2014|
OTTHUMP00000039771; TREM2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a
TREM-2; TREM2; Trem2a; Trem2b; Trem2c