|Western Blot (WB)||1:300-1:3000|
|Tested Species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the 4th cytoplasmic loop of rat TRPV6 conjugated to an immunogenic carrier protein|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5, heterotetramer. Expressed in duodenum, proximal jejunum, cecum, and colon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcium transport protein 1; CaT1; ECaC2; epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; osmosensitive transient receptor potential channel 3; Transient receptor potential cation channel subfamily V member 6; transient receptor potential cation channel, subfamily 5, member 6; TrpV6
Gene Aliases: CaT1; Ecac2; Otrpc3; Trpv6
UniProt ID: (Rat) Q9R186
Entrez Gene ID: (Rat) 114246
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