Search
Proteintech
TWIST1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
25465-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TWIST1-specific Fusion Protein Ag21924 (12-72 aa encoded by BC036704)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Amount
57 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody reacts specifically with TWIST1 protein.
Immunogen sequence: PADDSLSNS EEEPDRQQPP SGKRGGRKRR SSRRSAGGGA GPGGAAGGGV GGGDEPGSPA QG (12-72 aa encoded by BC036704)
Target Information
TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-HLH DNA binding protein; bHLHa38; Class A basic helix-loop-helix protein 38; H-twist; p ACS3; twist basic helix-loop-helix transcription factor 1; twist homolog 1; TWIST homolog of drosophila; Twist-related protein 1
Gene Aliases: ACS3; BHLHA38; BPES2; BPES3; CRS; CRS1; CSO; SCS; SWCOS; TWIST; TWIST1
UniProt ID: (Human) Q15672
Entrez Gene ID: (Human) 7291
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
bHLH transcription factor binding
protein dimerization activity
E-box binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
in utero embryonic development
neuron migration
neural tube closure
aortic valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of transcription from RNA polymerase II promoter
muscle organ development
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of macrophage cytokine production
cell differentiation
embryonic limb morphogenesis
positive regulation of cell migration
regulation of bone mineralization
positive regulation of fatty acid beta-oxidation
developmental process
negative regulation of tumor necrosis factor production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
hindlimb morphogenesis
negative regulation of peroxisome proliferator activated receptor signaling pathway
outer ear morphogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of cell differentiation
negative regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
negative regulation of skeletal muscle tissue development
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
stem cell differentiation
negative regulation of protein kinase B signaling
cranial suture morphogenesis
embryonic camera-type eye formation
eyelid development in camera-type eye
cardiac neural crest cell development involved in outflow tract morphogenesis
cellular response to hypoxia
positive regulation of monocyte chemotactic protein-1 production
energy homeostasis
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
positive regulation of cell motility
negative regulation of cellular senescence
negative regulation of double-strand break repair
cell proliferation involved in heart valve development
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support