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Invitrogen
TYRO3 Polyclonal Antibody
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FIGURE: 1 / 4
TYRO3 Antibody (PA5-22999) in ICC/IF
Immunocytochemistry analysis of TYRO3 in HeLa cells. Samples were incubated with TYRO3 polyclonal antibody (Product # PA5-22999) using a dilution of 1:200 followed by Dylight-488 conjugated goat anti-rabbit secondary antibody. Nuclei were visualized using Hoechst 33258 (Blue).
Product Details
PA5-22999
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an internal portion of the human TYRO3 protein (within residues 100-250).
Conjugate
Form
Liquid
Concentration
1.19 mg/mL
Amount
119 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The target sequence has 94% sequence homology with rat.
Suggested positive control: normal human brain lysate, normal mouse brain lysate.
Target Information
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; unnamed protein product
Gene Aliases: AI323366; Brt; BYK; DTK; Etk-2; etk2/tyro3; Rek; RSE; SKY; TIF; TK19-2; TYRO3
UniProt ID: (Human) Q06418, (Mouse) P55144
Entrez Gene ID: (Human) 7301, (Mouse) 22174
nucleotide binding
virus receptor activity
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
phosphatidylinositol 3-kinase binding
transferase activity, transferring phosphorus-containing groups
protein heterodimerization activity
transmembrane signal receptor
neuron migration
natural killer cell differentiation
phagocytosis
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
neuropeptide signaling pathway
spermatogenesis
nervous system development
cell migration
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
lymphocyte activation
viral entry into host cell
negative regulation of inflammatory response
negative regulation of lymphocyte activation
neuron apoptotic process
establishment of localization in cell
positive regulation of protein kinase B signaling
vagina development
neuron cellular homeostasis
platelet aggregation
positive regulation of viral life cycle
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
protein autophosphorylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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