|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||5 ug/mL|
|Immunohistochemistry (IHC)||2.5 ug/mL|
|Western Blot (WB)||1 ug/mL|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 15 amino acid synthetic peptide near the amino terminus of human VKORC1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is A549 cell lysate.
PA5-34358 can be used with blocking peptide PEP-1401.
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EDTP308; MST134; MST576; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex, subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); VKCFD2; VKOR; VKORC1
Gene Aliases: D7Wsu86e; EDTP308; MST134; MST576; MSTP134; MSTP576; UNQ308/PRO351; VKCFD2; VKOR; VKORC1
Molecular Function: oxidoreductase
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