Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
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Protein Aliases: FLJ14848; hVPS33B; r-vps33b; vacuolar protein sorting 33 homolog B; vacuolar protein sorting 33-like protein B; vacuolar protein sorting 33B; vacuolar protein sorting homolog r-vps33b; Vacuolar protein sorting-associated protein 33B; vacuolar sorting protein 33b; vps33b
Gene Aliases: VPS33B; zgc:110803
Molecular Function: membrane trafficking regulatory protein