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Proteintech
Vinculin Polyclonal Antibody
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Product Details
26520-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Vinculin Fusion Protein Ag24942 (777-1066 aa encoded by BC039174)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PKFREAVKA ASDELSKTIS PMVMDAKAVA GNISDPGLQK SFLDSGYRIL GAVAKVREAF QPQEPDFPPP PPDLEQLRLT DELAPPKPPL PEGEVPPPRP PPPEEKDEEF PEQKAGEVIN QPMMMAARQL HDEARKWSSK GNDIIAAAKR MALLMAEMSR LVRGGSGTKR ALIQCAKDIA KASDEVTRLA KEVAKQCTDK RIRTNLLQVC ERIPTISTQL KILSTVKATM LGRTNISDEE SEQATEMLVH NAQNLMQSVK ETVREAEAAS IKIRTDAGFT LRWVRKTPWY Q (777-1066 aa encoded by BC039174)
Target Information
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis luminal protein 114; epididymis secretory sperm binding protein; meta-vinculin; Metavinculin; MV; RP11-178G16.3; unnamed protein product; vinc; Vinculin
Gene Aliases: 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; HEL114; MV; MVCL; VCL; VINC
UniProt ID: (Human) P18206, (Mouse) Q64727
Entrez Gene ID: (Human) 7414, (Mouse) 22330
morphogenesis of an epithelium
cell adhesion
cell-matrix adhesion
lamellipodium assembly
regulation of cell migration
negative regulation of cell migration
adherens junction assembly
protein localization to cell surface
maintenance of blood-brain barrier
apical junction assembly
axon extension
regulation of focal adhesion assembly
platelet aggregation
epithelial cell-cell adhesion
regulation of establishment of endothelial barrier
regulation of protein localization to cell-cell adherens junction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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