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Proteintech

WNT1 Polyclonal Antibody

32 References
View all (12) WNT1 antibodies

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Product Details

27935-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 27 publications 27 publications

Immunohistochemistry (IHC)

-
View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

WNT1 Fusion Protein Ag27380

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

300 µg/mL

Amount

45 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal. The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor. Extensive research has shown that deregulation of these pathways or its components can lead to cancer. Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form. At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways. Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis. Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Proto-oncogene Int-1; Proto-oncogene Int-1 homolog; proto-oncogene protein Wnt-1; Proto-oncogene Wnt-1; wingless-related MMTV integration site 1; wingless-type MMTV integration site family member 1; wingless-type MMTV integration site family, member 1 (oncogene INT1)

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Gene Aliases: BMND16; Int-1; INT1; OI15; sw; swaying; Wnt-1; WNT1

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UniProt ID: (Human) P04628, (Mouse) P04426

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Entrez Gene ID: (Human) 7471, (Mouse) 22408

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Function(s)
receptor binding frizzled binding cytokine activity morphogen activity protein domain specific binding receptor agonist activity protein binding transcription regulatory region DNA binding intercellular signal molecule
Process(es)
embryonic axis specification branching involved in ureteric bud morphogenesis cell-cell signaling myoblast fusion cell proliferation positive regulation of cell proliferation response to wounding positive regulation of lamellipodium assembly negative regulation of cell-substrate adhesion myotube differentiation Wnt signaling pathway spinal cord association neuron differentiation diencephalon development cerebellum development central nervous system morphogenesis cerebellum formation forebrain anterior/posterior pattern specification midbrain-hindbrain boundary maturation during brain development neurogenesis metencephalon development negative regulation of cell-cell adhesion neuron differentiation negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway midbrain development midbrain-hindbrain boundary development organ regeneration T cell differentiation in thymus cell proliferation in midbrain astrocyte-dopaminergic neuron signaling inner ear morphogenesis signal transduction in response to DNA damage negative regulation of apoptotic process positive regulation of insulin-like growth factor receptor signaling pathway cell fate commitment fat cell differentiation negative regulation of cell differentiation negative regulation of fat cell differentiation positive regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation neuron fate commitment neuron fate determination Spemann organizer formation canonical Wnt signaling pathway bone development positive regulation of dermatome development hepatocyte differentiation cellular response to peptide hormone stimulus hematopoietic stem cell proliferation dopaminergic neuron differentiation positive regulation of hematopoietic stem cell proliferation negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway midbrain dopaminergic neuron differentiation embryonic brain development negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of cellular senescence positive regulation of protein phosphorylation signal transduction multicellular organism development organ morphogenesis BMP signaling pathway ubiquitin-dependent SMAD protein catabolic process canonical Wnt signaling pathway involved in negative regulation of apoptotic process positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of cell aging
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