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Bethyl Laboratories
XPA Polyclonal Antibody
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Product Details
IHC-00344-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Between 1 and 50
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
2 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; Xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP group A complementing
Gene Aliases: AI573865; XP1; XPA; XPAC
UniProt ID: (Human) P23025, (Mouse) Q64267
Entrez Gene ID: (Human) 7507, (Mouse) 22590
nucleotide-excision repair, DNA damage recognition
DNA repair
base-excision repair
nucleotide-excision repair
cellular response to DNA damage stimulus
response to oxidative stress
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
response to toxic substance
UV protection
regulation of autophagy
protein localization to nucleus
multicellular organism growth
positive regulation of transcription initiation from RNA polymerase II promoter
UV-damage excision repair
nucleotide-excision repair involved in interstrand cross-link repair
nucleotide-excision repair, DNA incision
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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