Search
Proteintech
ZEB1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
21544-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZEB1 Fusion Protein Ag16204 (391-740 aa encoded by BC112392)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
Immunogen sequence: MVQAVVLPT VGLVSPISIN LSDIQNVLKV AVDGNVIRQV LENNQANLAS KEQETINASP IQQGGHSVIS AISLPLVDQD GTTKIIINYS LEQPSQLQVV PQNLKKENPV ATNSCKSEKL PEDLTVKSEK DKSFEGGVND STCLLCDDCP GDINALPELK HYDLKQPTQP PPLPAAEAEK PESSVSSATG DGNLSPSQPP LKNLLSLLKA YYALNAQPSA EELSKIADSV NLPLDVVKKW FEKMQAGQIS VQSSEPSSPE PGKVNIPAKN NDQPQSANAN EPQDSTVNLQ SPLKMTNSPV LPVGSTTNGS RSSTPSPSPL NLSSSRNTQG YLYTAEGAQE EPQVEPLDLS L (391-740 aa encoded by BC112392)
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Delta EF1; delta-crystallin enhancer binding factor 1; DELTA-EF1; MEB1; MGC133261; Negative regulator of IL2; NIL-2-A; NIL-2-A zinc finger protein; NIL-2A; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; RP11-472N13.4; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; unnamed protein product; Zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; zinc finger homeodomain enhancer-binding protein
Gene Aliases: 3110032K11Rik; [delta]EF1; AREB6; BZP; DELTAEF1; FECD6; MEB1; Nil2; NIL2A; PPCD3; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZFHEP; ZFHX1A; Zfx1a; Zfx1ha
UniProt ID: (Human) P37275, (Mouse) Q64318
Entrez Gene ID: (Human) 6935, (Mouse) 21417
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
metal ion binding
E-box binding
nucleic acid binding
double-stranded DNA binding
transcription factor binding
sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
pattern specification process
nervous system development
central nervous system development
cell proliferation
regulation of mesenchymal cell proliferation
negative regulation of keratinocyte proliferation
regulation of transforming growth factor beta receptor signaling pathway
cell differentiation
negative regulation of epithelial cell differentiation
regulation of T cell differentiation in thymus
keratinocyte proliferation
negative regulation of endothelial cell differentiation
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
animal organ development
embryonic camera-type eye morphogenesis
embryonic morphogenesis
embryonic skeletal system morphogenesis
semicircular canal morphogenesis
epithelial cell proliferation
negative regulation of epithelial cell proliferation
regulation of smooth muscle cell differentiation
cartilage development
cellular response to amino acid stimulus
cochlea morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support