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Product Details
PA5-97020
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 170-390 of human ZP3 (NP_0011038241)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808822
Product Specific Information
Immunogen sequence: LTFSLRLMEE NWNAEKRSPT FHLGDAAHLQ AEIHTGSHVP LRLFVDHCVA TPTPDQNASP YHTIVDFHGC LVDGLTDASS AFKVPRPGPD TLQFTVDVFH FANDSRNMIY ITCHLKVTLA EQDPDELNKA CSFSKPSNSW FPVEGSADIC QCCNKGDCGT PSHSRRQPHV MSQWSRSASR NRRHVTEEAD VTVGPLIFLD RRGDHEVEQW ALPSDTSVVL L; Positive Samples: SKOV3; Cellular Location: Cell membrane, Single-pass type I membrane protein, extracellular matrix, extracellular space
Target Information
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Sperm receptor; Zona pellucida glycoprotein 3; zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida glycoprotein ZP3; Zona pellucida protein C; Zona pellucida sperm-binding protein 3; Zp-3; ZP3A/ZP3B
Gene Aliases: Zp-3; ZP3; ZP3A; ZP3B; ZPC
UniProt ID: (Human) P21754, (Rat) P97708
Entrez Gene ID: (Human) 7784, (Rat) 114639
positive regulation of type IV hypersensitivity
blastocyst formation
humoral immune response mediated by circulating immunoglobulin
positive regulation of leukocyte migration
positive regulation of humoral immune response
manganese ion transport
intracellular protein transport
binding of sperm to zona pellucida
positive regulation of phosphatidylinositol biosynthetic process
positive regulation of interferon-gamma production
positive regulation of interleukin-4 production
intracellular signal transduction
egg coat formation
positive regulation of T cell proliferation
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
phosphatidylinositol-mediated signaling
oocyte development
positive regulation of inflammatory response
positive regulation of protein kinase B signaling
protein kinase C signaling
calcium ion transmembrane transport
manganese ion transmembrane transport
positive regulation of calcium ion import
positive regulation of acrosome reaction
negative regulation of binding of sperm to zona pellucida
positive regulation of acrosomal vesicle exocytosis
positive regulation of ovarian follicle development
positive regulation of antral ovarian follicle growth
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