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Proteintech
iPLA2 Polyclonal Antibody
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Product Details
22030-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
iPLA2 Fusion Protein Ag16896 (1-343 aa encoded by BC036742)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MQFFGRLVN TFSGVTNLFS NPFRVKEVAV ADYTSSDRVR EEGQLILFQN TPNRTWDCVL VNPRNSQSGF RLFQLELEAD ALVNFHQYSS QLLPFYESSP QVLHTEVLQH LTDLIRNHPS WSVAHLAVEL GIRECFHHSR IISCANCAEN EEGCTPLHLA CRKGDGEILV ELVQYCHTQM DVTDYKGETV FHYAVQGDNS QVLQLLGRNA VAGLNQVNNQ GLTPLHLACQ LGKQEMVRVL LLCNARCNIM GPNGYPIHSA MKFSQKGCAE MIISMDSSQI HSKDPRYGAS PLHWAKNAEM ARMLLKRGCN VNSTSSAGNT ALHVAVMRNR FDCAIVLLTH GANA (1-343 aa encoded by BC036742)
Target Information
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2; iPLA2-beta; neurodegeneration with brain iron accumulation 2; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent); PLA2G6; PNPLA9; unnamed protein product
Gene Aliases: BB112799; CaI-PLA2; GVI; INAD1; iPLA(2)beta; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PLA2G6; PLPLA9; PNPLA9
UniProt ID: (Human) O60733, (Mouse) P97819
Entrez Gene ID: (Human) 8398, (Mouse) 53357
1-alkyl-2-acetylglycerophosphocholine esterase activity
lysophospholipase activity
phospholipase A2 activity
protein binding
calmodulin binding
hydrolase activity
serine hydrolase activity
identical protein binding
calcium-independent phospholipase A2 activity
long-chain acyl-CoA hydrolase activity
protein kinase binding
ATP-dependent protein binding
phospholipase
lipid metabolic process
chemotaxis
antibacterial humoral response
phosphatidylcholine catabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
cardiolipin acyl-chain remodeling
Fc-gamma receptor signaling pathway involved in phagocytosis
phosphatidylethanolamine catabolic process
platelet activating factor metabolic process
phosphatidic acid metabolic process
positive regulation of ceramide biosynthetic process
positive regulation of protein phosphorylation
positive regulation of cytosolic calcium ion concentration
memory
metabolic process
urinary bladder smooth muscle contraction
lipid catabolic process
cardiolipin biosynthetic process
response to endoplasmic reticulum stress
positive regulation of vasodilation
positive regulation of exocytosis
negative regulation of synaptic transmission, glutamatergic
positive regulation of protein kinase C signaling
positive regulation of release of cytochrome c from mitochondria
positive regulation of arachidonic acid secretion
regulation of store-operated calcium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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