Expedited screening improves outcomes for individuals with drug toxicity
In the field of clinical research and toxicology, the detection and quantification of drugs in human samples with suspected drug overdose or acute drug toxicity are critical. This blog post explores the potential of paper spray mass spectrometry (PS-MS) such as Thermo Scientific VeriSpray PaperSpray ion source, for faster and more efficient drug toxicity screening in emergency room applications.
Researchers from King’s College London (KCL) are collaborating with Guy’s and St Thomas’ NHS Foundation Trust and leveraging the capabilities of paper spray-mass spectrometry (PS-MS) to analyze blood samples from individuals with acute drug toxicity in the emergency room. The aim is to develop routine methods for detecting and quantifying drugs, ultimately improving health outcomes for individuals in need of immediate care and making drug toxicity screening at the bedside a possibility in the future.
KCL researchers are conducting extensive testing and optimization of PS-MS technology. Preliminary results shared at The International Association of Forensic Toxicologists (TIAFT) 2023 annual meeting in Rome have shown promising linearity across various concentrations for a number of cathinones. The goal is to refine the process and enhance accuracy, with the potential implementation of PS-MS into clinical practice.
Advantages of VeriSpray PaperSpray mass spectrometry
PS-MS with the Thermo Scientific™ TSQ Altis™ Plus Triple Quadrupole mass spectrometer offers several advantages over traditional orthogonal techniques. It enables rapid analysis, eliminating the need for lengthy sample preparation and chromatography-based separation. Additionally, the technique provides quantitative or screening results, is easy to use, reduces the risk of cross-contamination, and has barcoded tracking for LIMS compatibility with robotic automated systems such as Hamilton. Plus, it minimizes the use of chemicals and solvents, making it more environmentally friendly.
PS-MS offers a fast (2 minutes or less) turnaround time for high-throughput screening, enabling quick analysis of single samples from individuals and identify the presence of drugs or substances. The system’s ease of use and ability to process 240 samples unattended make it efficient and time-saving. The aim is to make drug toxicity screening at the bedside a reality, reducing waiting times for results and improving overall care.
Great potential for POC toxicity screening
The collaboration between KCL, Guy’s and St Thomas’ NHS Foundation Trust, and research on PS-MS holds great potential for improving point-of-care drug toxicity screening. PS-MS offers a rapid, efficient, and accurate alternative to traditional methods, enabling faster and more efficient care for individuals presenting with acute drug toxicity. By implementing this technology, hospitals can reduce waiting times and ultimately improve outcomes in emergency settings. To learn more, download the recent case study.
Related information
- Thermofisher.com/verispray
- Toxicology in the emergency department: what’s new?
- Thermo Fisher Scientific collaboration offers potential for faster, more efficient analysis of samples from drug toxicity patients
- Paper spray mass spectrometry simplifies and expedites turnaround of drug toxicity screening: Thermo Fisher Scientific Case Study