Is <a href="https://www.thermofisher.com/us/en/home/bioprocessing/products/chromatography-purification/bioprocess-resins/protein-a-resins.html">Protein A</a> still relevant for modern antibody purification?

Yes, Protein A remains a highly effective and widely used method for many antibody formats, including some next-generation molecules.

Why consider additional purification strategies beyond Protein A?

Complex antibody structures often require higher resolution or alternative binding approaches to effectively separate impurities and ensure product quality.

What are <a href="https://www.thermofisher.com/us/en/home/bioprocessing/products/chromatography-purification/bioprocess-resins/affinity-resins.html">subdomain-specific ligands</a>?

They are engineered affinity ligands that target specific regions of an antibody, such as light chains or CH1 domains, enabling more tailored purification.

Do subdomain-specific methods replace Protein A?

No, they are typically used as complementary tools to enhance purification performance alongside established methods.

Are these approaches suitable for large-scale manufacturing?

Yes, when properly implemented, they support scalable and reproducible workflows aligned with regulatory standards.

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