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Neurobiology experiments built on cell biology technologies
Publication-backed tools and reagents designed to support every stage of your neurobiology experiments. From establishing physiologically relevant cell models to detecting and analyzing cellular changes, our solutions help you generate reliable, reproducible results with confidence. To make it easier to find the right resources for your experiments, we've organized our neurobiology portfolio around the key stages of the research workflow: culture, modification, detection, and analysis. Explore each workflow step below to discover the tools, reagents, and resources that can help accelerate your research and bring you from cell culture to meaningful conclusions.
Advancing discovery across neurobiology research
Culture—solutions to help establish stable cell models
Neurobiology culture solutions including media, supplements and substrates that support consistent cell identity, baseline stability, and physiologically relevant behavior over time in neural cell models, including primary rodent neurons, human neural cells, iPSCs, and 2D and 3D cultures.
Modify—implementable tools for controlled experimental challenges
Implementable tools that support clear cause–effect relationships and controlled experimental challenges, all while preserving often fragile culture conditions.
Research spotlight: Scientists Recreate Early Neuroblastoma Development in Human Stem Cells
Researchers modelled neuroblastoma-associated chromosomal aberrations in human embryonic stem cells, using the Neon NxT Electroporation System to engineer MYCN-inducible stem cell lines and investigate how developmental mutations drive tumour initiation.
Technical guidance: Lipid-Mediated Transfection of Human Astrocytes
Optimize plasmid DNA and siRNA delivery into primary human astrocytes with this lipid-mediated transfection protocol featuring Lipofectamine LTX and RNAiMAX reagents. Includes guidance for cell preparation, matrix coating, and transfection conditions to help maximize efficiency while reducing cytotoxicity.
Technical guidance: Transfection of NSCs with Lipofectamine Stem Transfection Reagent in StemPro Medium
Streamline transfection of human neural stem cells using Lipofectamine Stem Transfection Reagent in StemPro NSC Serum-Free Medium. This protocol offers optimized conditions for DNA, mRNA, and CRISPR/Cas9 RNP delivery while supporting high transfection efficiency, cell viability, and stem cell maintenance.
Detect—solutions for sensitive functional and phenotypic readouts
Solutions from ion indicators to mitochondrial assays and ligand internalization that support clear functional and phenotypic readouts and sensitivity without added noise allowing for detection of subtle culture differences.
Research spotlight: Scientists uncover how mitophagy protects against manganese-induced neuroinflammation
Researchers demonstrated that impaired mitophagy drives mitochondrial dysfunction and inflammatory STING signaling in models of manganese-induced parkinsonism. Using Invitrogen MitoSOX Red, MitoTracker Green, and Invitrogen antibodies against PINK1, Parkin, and phospho-Parkin along with other tools, the team characterized mitochondrial oxidative stress and mitophagy defects and showed that restoring mitochondrial quality control reduced neuroinflammatory injury.
Measuring Neuronal Cell Health through Viability and Neurite Outgrowth
Learn how to assess neuronal cell health using fluorescence-based assays for viability, cytotoxicity, neurite outgrowth, oxidative stress, and mitochondrial function to support neurobiology research and drug discovery workflows.
Practical Considerations for Choosing a Cell-Based Assay for Microplate Readers
Discover key considerations for selecting cell-based assays for microplate readers, including assay type, detection method, sensitivity, throughput, and workflow compatibility to support reliable and reproducible results.
Analyze—instruments and microscopes to easily capture, analyze, and quantify cellular data
Scalable analytical solutions to help turn the volume and complexity of neurobiology data into scientific understanding.
Multiplex neuroscience panels
Get a deeper and more thorough understanding of the progression of neuroinflammation and neurodegenerative diseases by identifying and quantitating multiple biomarkers in blood and cerebrospinal fluid (CSF) simultaneously.
Poster: Antibodies for neuroscience research
Use this free poster to easily find the markers you need for your neuroscience research.
- Quick reference guide for neuroscience markers
- Cell-type specific antibody recommendations
- Common markers for neurons, astrocytes, microglia, and oligodendrocytes
- Suitable for IF, IHC, ICC, and related applications
Optimized protein extraction reagent for neuronal tissue and primary cells
Learn an optimized method for extracting proteins from neuronal tissues and cells, including guidance on lysis conditions, sample preparation, and preservation of protein integrity for downstream neurobiology applications.
For Research Use Only. Not for use in diagnostic procedures.