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Invitrogen

ANP Recombinant Rabbit Monoclonal Antibody (17H19L1)

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ANP Recombinant Rabbit Monoclonal Antibody (17H19L1)

Product Details

702539

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

17H19L1

Immunogen

Peptide corresponding to human NPPA(ANP) (aa127-145)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2-7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662340

Product Specific Information

This antibody is predicted to react with Monkey, Cat, Pig

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: atrial natriuretic factor; atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; atriopeptin; cardiodilatin; cardiodilatin-related peptide; cardionatrin; natriuretic peptide precursor A; Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; preproANF; preproANP; preprocardiodilatin-atrial natriuretic factor; preproCDD-ANF; prepronatiodilatin (PND); prepronatriodilatin; proANF; proANP; Pronatriodilatin; unnamed protein product; urodilatin

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Gene Aliases: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; PND; RATANF

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UniProt ID: (Human) P01160, (Mouse) P05125, (Rat) P01161

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Entrez Gene ID: (Human) 4878, (Mouse) 230899, (Rat) 24602

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Function(s)
receptor binding hormone activity neuropeptide hormone activity protein binding hormone receptor binding neuropeptide receptor binding guanylate cyclase activator activity
Process(es)
response to hypoxia system process negative regulation of systemic arterial blood pressure cGMP biosynthetic process protein folding receptor guanylyl cyclase signaling pathway neuropeptide signaling pathway female pregnancy regulation of blood pressure positive regulation of heart rate cardiac muscle hypertrophy in response to stress negative regulation of cell growth response to insulin sodium ion export from cell negative regulation of epidermal growth factor receptor signaling pathway regulation of vascular permeability negative regulation of JUN kinase activity negative regulation of blood pressure cGMP metabolic process regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction cell growth involved in cardiac muscle cell development cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to glucose stimulus negative regulation of canonical Wnt signaling pathway synaptic signaling via neuropeptide regulation of calcium ion transmembrane transport via high voltage-gated calcium channel positive regulation of potassium ion export across plasma membrane negative regulation of collecting lymphatic vessel constriction cellular response to angiotensin response to 3-methylcholanthrene cardiac conduction system development aortic valve morphogenesis response to muscle stretch heart development regulation of body fluid levels multicellular organismal water homeostasis
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