iodoTMTsixplex™ Isobaric Mass Tagging Kit

Catalog number: 90103

Thermo Scientific™  Related applications: Protein Mass Spectrometry Analysis

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The Thermo Scientific iodoTMTsixplex Isobaric Mass Tag Labeling Kit contains iodoTMT™ reagents and associated materials for the irreversible labeling of sulfhydryl groups.

Thermo Scientific iodoTMTsixplex Label Reagents enables enable concurrent identification and multiplexed quantitation of proteins in different samples using tandem mass spectrometry. The iodoTMT™ Reagents are sets of isobaric (mass and structure) isomers that are iodoacetyl-activated for covalent, irreversible labeling of sulfhydryl (—SH) groups. Similar to iodoacetamide, iodoTMT Reagents react specifically with reduced cysteines (Cys) in peptides and proteins. IodoTMT Reagents can be differentiated by mass spectrometry (MS), enabling quantitation of the relative abundance of cysteine modifications, such as S-nitrosylation, oxidation and disulfide bonds, in cultured cells grown or treated with different conditions.

Features of iodoTMTsixplex Label Reagents:

Specific—only reacts with sulfhydryl groups (reduced, unmodified cysteine residues)
Irreversible—labeled proteins and peptides are not susceptible to reducing agents
Flexible—options for duplex isotopic (MS) or sixplex isobaric (MS/MS) quantitation
Versatile—can be used to study cysteine modifications (e.g. di-sulfide bridges, S-nitrosylation)

IodoTMT Products replace our previously offered CysTMT™ Reagents, which utilized a dithiopyridine reactive group to reversibly label cysteine sulfhydryls. For information about customized reagent sets, please contact our Large Volume and Custom Sales Department.

These products are subject to a limited use label license.

More Product Data
Specific labeling, enrichment and quantitation of S-nitrosylated peptides using iodoTMT reagents

Related Products
iodoTMTsixplex™ Label Reagent Set, 1 x 0.2 mg
iodoTMTzero™ Label Reagent, 5 x 0.2 mg
Immobilized Anti-TMT™ Antibody Resin
TMT™ Elution Buffer

For Research Use Only. Not for use in diagnostic procedures.


Product Size: 30 reactions
Workflow Step: Protein Labeling
Detection Method: Mass Spectrometry
Starting Material: Cell Lysate
For Use With (Equipment): Mass Spectrometer

Contents & storage

• iodoTMT6-126 Label Reagent, 5 x 0.2 mg
• iodoTMT6-127 Label Reagent, 5 x 0.2 mg
• iodoTMT6-128 Label Reagent, 5 x 0.2 mg
• iodoTMT6-129 Label Reagent, 5 x 0.2 mg
• iodoTMT6-130 Label Reagent, 5 x 0.2 mg
• iodoTMT6-131 Label Reagent, 5 x 0.2 mg
• HES Buffer, 15 mL
• Bond-Breaker TCEP Solution, 0.5 mL
• DTT, No-Weigh Format, 8 x 7.7 mg
• Trypsin, 5 x 20 µg
• Trypsin Storage Solution, 250 µL
• Albumin (bovine), 2.5 mg

Upon receipt store all products at -20°C


Manuals & protocols

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