Invitrogen™

DCAMKL1 (DCLK1) Recombinant Human Protein

Catalog number:  A33355

Related applications:

Pharma & Biopharma

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Description

This DCAMKL1 (DCLK1) recombinant human protein (full length) was expressed in insect cells. DCAMKL1 (DCLK1) serine/threonine kinase or DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. DCAMKL1 (DCLK1) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_004725
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Full Length, Recombinant, Active
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 107.4 kDa
KinaseFamily: DCAMKL Kinase Family
Protein Length: Full Length
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.