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Alomone Labs, LTD
GPR143 Polyclonal Antibody
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FIGURE: 1 / 5
GPR143 Antibody (AGR-083-25UL) in IHC (F)
Expression of GPR143 in mouse striatum. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Anti-GPR143 Antibody (#AGR-083) (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. GPR143 immunoreactivity (green) appears in the ventral striatum region (arrows). B. Pre-incubation of the antibody with GPR143 Blocking Peptide (BLP-GR083), suppressed staining. Cell nuclei are stain... View More
Product Details
AGR-083-25UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide RDKYEPAAVSEHGD, corresponding to amino acid residues 7- 20 of rat ATP1A1. Intracellular, N-terminus.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: RDKYEPAAVSEHGD
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes. Defects in GPR143 are the cause of ocular albinism type 1 (OA1); also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor 143; homolog of human ocular albinism 1 (Nettleship-Falls); MOA1; OA1; ocular albinism 1; Ocular albinism type 1 protein; Ocular albinism type 1 protein homolog
Gene Aliases: GPR143; NYS6; OA1; RGD1565799
UniProt ID: (Human) P51810, (Mouse) P70259
Entrez Gene ID: (Human) 4935, (Mouse) 18241, (Rat) 302619
eye pigment biosynthetic process
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
visual perception
melanosome localization
melanosome transport
melanosome organization
regulation of melanosome transport
regulation of melanosome organization
chemical synaptic transmission
calcium-mediated signaling using intracellular calcium source
phosphatidylinositol-mediated signaling
regulation of calcium-mediated signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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