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Abnova
HDAC4 Polyclonal Antibody, MaxPab™
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Product Details
H00009759-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HDAC4 (AAH39904.1, 1 a.a. approximately 972 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLAMKHQQEL LEHQRKLERH RQEQELEKQH REQKLQQLKN KEKGKESAVA STEVKMKLQE FVLNKKKALA HRNLNHCISS DPRYWYGKTQ HSSLDQSSPP QSGVSTSYNH PVLGMYDAKD DFPLRKTASE PNLKLRSRLK QKVAERRSSP LLRRKDGPVV TALKKRPLDV TDSACSSAPG SGPSSPNNSS GSVSAENGIA PAVPSIPAET SLAHRLVARE GSAAPLPLYT SPSLPNITLG LPATGPSAGT AGQQDAERLT LPALQQRLSL FPGTHLTPYL STSPLERDGG AAHSPLLQHM VLLEQPPAQA PLVTDWYLSG LGALPLHAQS LVGADRVSPS IHKLRQHRPL GRTQSAPLPQ NAQALQHLVI QQQHQQFLEK HKQQFQQQQL QMNKIIPKPS EPARQPESHP EETEEELREH QALLDEPYLD RLPGQKEAHA QAGVQVKQEP IESDEEEAEP PREVEPGQRQ PSEQELLFRQ QALLLEQQRI HQLRNYQASM EAAGIPVSFG GHRPLSRAQS SPASATFPVS VQEPPTKPRF TTGLVYDTLM LKHQCTCGSS SSHPEHAGRI QSIWSRLQET GLRGKCECIR GRKATLEELQ TVHSEAHTLL YGTNPLNRQK LDSKKLLGSL ASVFVRLPCG GVGVDSDTIW NEVHSAGAAR LAVGCVVELV FKVATGELKN GFAVVRPPGH HAEESTPMGF CYFNSVAVAA KLLQQRLSVS KILIVDWDVH HGNGTQQAFY SDPSVLYMSL HRYDDGNFFP GSGAPDEVGT GPGVGFNVNM AFTGGLDPPM GDAEYLAAFR TVVMPIASEF APDVVLVSSG FDAVEGHPTP LGGYNLSARC FGYLTKQLMG LAGGRIVLAL EGGHDLTAIC DASEACVSAL LGNELDPLPE KVLQQRPNAN AVRSMEKVME IHSKYWRCLQ RTTSTAGRSL IEAQTCENEE AETVTAMASL SVGVKPAEKR PDEEPMEEEP PL
Target Information
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp779K1053; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0744; MITR; unnamed protein product
Gene Aliases: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288; NEDCHF; NEDCHID
UniProt ID: (Human) P56524
Entrez Gene ID: (Human) 9759
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
zinc ion binding
hydrolase activity
SUMO transferase activity
potassium ion binding
protein deacetylase activity
histone binding
identical protein binding
histone deacetylase binding
metal ion binding
binding, bridging
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
protein deacetylation
inflammatory response
nervous system development
positive regulation of cell proliferation
negative regulation of macromolecule biosynthetic process
negative regulation of myotube differentiation
negative regulation of transcription by competitive promoter binding
response to denervation involved in regulation of muscle adaptation
cardiac muscle hypertrophy in response to stress
protein sumoylation
B cell differentiation
positive regulation of protein sumoylation
regulation of gene expression, epigenetic
B cell activation
negative regulation of gene expression, epigenetic
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
type I interferon signaling pathway
response to interleukin-1
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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