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Invitrogen
alpha Actinin 1 Monoclonal Antibody (BM 75.2)
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FIGURE: 1 / 4
alpha Actinin 1 Antibody (MA1-24910) in ICC/IF
Immunofluorescent analysis of alpha Actinin in acetone-fixed sections of human myocardium using an Alpha Actinin monoclonal antibody (Product # MA1-24910). The image shows the distribution of non-sarcomeric alpha-actinin in endothelial and smooth muscle cells of two blood vessels, whereas there is no fluorescence in the surrounding cardio-myocytes. The nuclei are stained red with propidium iodide.
Product Details
MA1-24910
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
BM 75.2
Immunogen
Cytoskeletal fraction of bovine mammary gland epithelium (BMGE) cultured cells.
Conjugate
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
MA1-24910 detects alpha Actinin from human, mouse samples.
MA1-24910 has been successfully used in Western blot, IF, ICC, and IDF procedures.
The MA1-24910 immunogen is cytoskeletal fraction of bovine mammary gland epithelium (BMGE) cultured cells.
Target Information
Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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