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Invitrogen
TBX1 Monoclonal Antibody (OTI1C2)
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FIGURE: 1 / 2
TBX1 Antibody (MA5-26348) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human lymph node tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a TBX1 monoclonal antibody (Product # MA5-26348).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-26348
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1C2
Immunogen
Full length human recombinant protein of TBX1 produced in HEK293T cell
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brachyury; T-box 1 transcription factor C; TBX1C; Testis-specific T-box protein; variant A; variant B
Gene Aliases: CAFS; CATCH22; CTHM; DGCR; DGS; DORV; TBX1C; TGA; VCF; VCFS
UniProt ID: (Human) O43435
Entrez Gene ID: (Human) 6899
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
protein dimerization activity
sequence-specific double-stranded DNA binding
angiogenesis
blood vessel development
cell fate specification
neural crest cell migration
positive regulation of protein phosphorylation
lymph vessel development
positive regulation of mesenchymal cell proliferation
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
muscle organ development
sensory perception of sound
cell proliferation
positive regulation of cell proliferation
anatomical structure morphogenesis
anterior/posterior pattern specification
vagus nerve morphogenesis
epithelial cell differentiation
thyroid gland development
somatic stem cell population maintenance
social behavior
aorta morphogenesis
ear morphogenesis
inner ear morphogenesis
outer ear morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
muscle cell fate commitment
positive regulation of MAPK cascade
tongue morphogenesis
cellular response to fibroblast growth factor stimulus
negative regulation of cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
blood vessel morphogenesis
thymus development
muscle organ morphogenesis
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
semicircular canal morphogenesis
artery morphogenesis
positive regulation of epithelial cell proliferation
parathyroid gland development
soft palate development
pharyngeal system development
face morphogenesis
muscle tissue morphogenesis
coronary artery morphogenesis
enamel mineralization
cellular response to retinoic acid
cochlea morphogenesis
mesenchymal cell apoptotic process
regulation of organ morphogenesis
positive regulation of tongue muscle cell differentiation
negative regulation of mesenchymal cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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