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Invitrogen
KLRB1 Recombinant Rabbit Monoclonal Antibody (008)
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Product Details
MA5-30977
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
008
Immunogen
Recombinant Mouse Klrb1a protein (67-227).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse Klrb1a.
Target Information
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type lectin-like receptor; CD161 antigen-like family member A; CD161 antigen-like family member B; immunoreceptor NKR-P1G; inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1G; lectin-like transmembrane protein Nkrp1g; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55A; lymphocyte antigen 55b; lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B; natural killer cell surface protein NKR-P1G; natural killer cell surface protein P1-2; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR-P1 2; NKR-P1 34; NKR-P1 gene-2 protein; NKR-P1 gene-34 protein; transmembrane protein; unnamed protein product
Gene Aliases: 4930431A04Rik; Gm4696; Klrb1d; Klrb1g; Klrb6; Ly-55; ly-55A; ly-55b; ly-55d; Ly55; Ly55a; Ly55b; Ly55d; NKR-P1.7; NKR-P1A; NKR-P1B; NKR-P1D; NKR-P1G; Nkrp-1e; Nkrp1-a; Nkrp1-b; NKRP12; Nkrp1a; Nkrp1b; Nkrp1d; Nkrp1g
UniProt ID: (Mouse) Q0ZUP1, (Mouse) P27811, (Mouse) Q99JB4
Entrez Gene ID: (Mouse) 100043861, (Mouse) 17057, (Mouse) 80782
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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