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Invitrogen
LDHA Recombinant Rabbit Monoclonal Antibody (23GB6060)
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FIGURE: 1 / 3
LDHA Antibody (MA5-52976) in ICC/IF
Immunocytochemistry analysis of LDHA in HepG2 cells. Sample was incubated with LDHA monoclonal (Product # MA5-52976) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Low. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-52976
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB6060
Immunogen
A synthesized peptide derived from human Lactate Dehydrogenase (254-300AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers. Mutations in the LDHA gene can lead to Glycogen storage disease 11 (GSD11).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P; L-lactate dehydrogenase; Lactate Dehydrogenase; lactate dehydrogenase 1, A chain; lactate dehydrogenase 3, C chain, sperm specific; lactate dehydrogenase A4; lactate dehydrogenase M; Lactic Dehydrogenase; LDH; LDH muscle subunit; LDH testis subunit; LDH-A; LDH-C; LDH-M; LDH-X; LDHA; M-LDH; OTTHUMP00000165206; PIG19; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59; unnamed protein product
Gene Aliases: CDK1; GSD11; HEL-S-133P; l7R2; Ldh1; Ldh3; LDHM; PIG19
UniProt ID: (Human) P00338, (Mouse) P06151, (Rat) P04642
Entrez Gene ID: (Human) 3939, (Mouse) 16828, (Rat) 24533, (Rat) 29634
lactate metabolic process
ATP biosynthetic process
lactate biosynthetic process from pyruvate
NAD metabolic process
sperm motility
pyruvate catabolic process
glycolytic process
substantia nigra development
response to hypoxia
liver development
skeletal muscle tissue development
response to nutrient
response to xenobiotic stimulus
response to glucose
response to hydrogen peroxide
positive regulation of apoptotic process
response to estrogen
response to cAMP
cellular response to phorbol 13-acetate 12-myristate
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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