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Invitrogen
Dengue Virus Type 1-4 NS2B (Thailand/16681/1984) Recombinant Rabbit Monoclonal Antibody (HL2513)
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FIGURE: 1 / 2
Dengue Virus Type 1-4 NS2B (Thailand/16681/1984) Antibody (MA5-56675) in ICC/IF
Immunocytochemistry analysis of Dengue virus infected cells using Dengue Virus Type 1-4 NS2B (Thailand/16681/1984) (Product # MA5-56675) on ZIKV, CHIKV, DENV 1, DENV2, DENV3, and DENV 4 infected cells slides. Green: Dengue Virus Type 1-4 NS2B diluted at 1:100. Blue: Fluoroshield with DAPI.
Product Details
MA5-56675
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2513
Immunogen
Full lengh of Dengue virus NS2B protein. (strain Thailand/16681/1984)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
The Dengue Virus Type 1-4 NS2B protein is a non-structural protein that is integral to the replication and maturation of the dengue virus, encompassing all four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). NS2B functions as a crucial cofactor for the NS3 protease, forming a complex that is essential for the cleavage of the viral polyprotein into its constituent proteins. These proteins are necessary for the assembly and replication of new viral particles within the host cell. NS2B is an integral membrane protein that not only aids in the proper folding and activation of the NS3 protease but also plays a role in the viral replication complex formation. Dengue virus is transmitted to humans primarily through the bites of Aedes mosquitoes and can cause dengue fever, characterized by symptoms such as high fever, severe headache, retro-orbital pain, joint and muscle pain, rash, and in severe cases, hemorrhagic manifestations or dengue shock syndrome. Given its pivotal role in the viral life cycle, the NS2B-NS3 protease complex is a significant target for antiviral drug development. Inhibiting this protease activity could potentially prevent viral replication and reduce the severity of the disease. Research into the structure and function of the NS2B protein across all four dengue virus serotypes is essential for developing broad-spectrum antiviral therapies and improving our understanding of dengue virus pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dengue Virus 1-4; DENV; DENV1-4
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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